Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction
نویسندگان
چکیده
منابع مشابه
M atrix metalloproteinase - 2 mediates cytokine - induced myocardial contractile dysfunction a b c b ́
Objective: Pro-inflammatory cytokines depress myocardial contractile function by enhancing peroxynitrite production, yet the mechanism by which peroxynitrite does this is unknown. As matrix metalloproteinases (MMPs) can be activated by peroxynitrite and can proteolytically cleave troponin I in hearts, we determined whether this occurs in cytokine-induced myocardial dysfunction. Methods: Isolate...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2003
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(02)00719-8